Investigating Mechanisms Of Genome Maintenance

Dan Semlow

Dan Semlow
2001-2005 B.S. Molecular and Cellular Biology The University of Illinois at Urbana Champaign
2006-2015 Ph.D. Molecular Genetics and Cell Biology The University of Chicago (supervisor, Jon Staley)
2015-Present Postdoctoral fellow Harvard Medical School (supervisor, Johannes Walter)
Awards and honors
2016-2018 Jane Coffin Childs Postdoctoral Fellow
2018-Present NIH Pathway to Independence Award
Wu, R.A., Semlow, D.R., Kamimae-Lanning, A.N., Kochenova, O.V., Chistol, G., Hodskinson, M.R., Amunugama, R., Sparks, J.L., Wang, M., Deng, L., Mimoso, C.A., Low, E., Patel, K.J., Walter, J.C. (2019). TRAIP is a master regulator of DNA interstrand crosslink repair. Nature. doi:10.1038/s41586-019-1002-0.
Semlow, D.R., Zhang, J., Budzowska, M., Drohat, A.C., Walter, J.C. (2016). Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase. Cell 167(2): 498-511.e14. doi:10.1016/j.cell.2016.09.008.
Semlow, D.R., Blanco, M.R., Walter, N.G., and Staley, J.P. (2016). Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites. Cell 164: 985-98.
Semlow, D.R. and Staley, J.P. (2012). Staying on message: ensuring fidelity in pre-mRNA splicing. Trends Biochem. Sci. 37: 263-73.
Mayas, R.M.*, Maita, H.*, Semlow, D.R.*, Staley, J.P. (2010). Spliceosome discards intermediates via the DEAH box ATPase Prp43p. Proc. Natl. Acad. Sci U.S.A. 107: 10020-5.
(* these authors contributed equally)
Semlow, D.R. and Silverman, S.K. (2005). Parallel selections in vitro reveal a preference for 2'-5' RNA ligation upon deoxyribozyme-mediated opening of a 2',3'-cyclic phosphate. J. Mol. Evol. 61: 207-15.
Prior, T.K., Semlow, D.R., Flynn-Charlebois, A., Rashid, I., and Silverman, S.K. (2004). Structure-function correlations derived from faster variants of a RNA ligase deoxyribozyme. Nucleic Acids Res. 32: 1075-82.
Alumni Date Graduated
Alumni Position
Assistant Professor, California Institute of Technology