Manal Zaher

Post-doc

617-432-2927

Education
2006-2010 B.A. in Mathematics and B.S. in Biology Bryn Mawr College
2008-2010 M.A. in Mathematics Bryn Mawr College
2011-2012 M.S. in Bioscience King Abdullah University of Science and Technology
2013-2019 Ph.D. in Bioscience King Abdullah University of Science and Technology (supervisor, Samir M. Hamdan)
2019-Present Postdoctoral fellow Harvard Medical School (supervisor, Johannes Walter)
Awards and honors
2010 Charlotte Angas Scott Prize in Mathematics
2009 MIT Lincoln Laboratory Research Award
Publications

Low, E., Chistol, G., Zaher, M. S., Kochenova, O. V.,  Walter, J. C. (2020). The DNA replication fork suppresses CMG unloading from chromatin before termination. Genes & development. 34(21-22): 1534-1545.

Lancey, C., Tehseen, M., Raducanu, V. S., Rashid, F., Merino, N., Ragan, T. J., Savva, C.G., Zaher, M.S., Shirbini, A., Blanco, F.J., Hamdan, S.M., De Biasio, A. (2020). Structure of the processive human Pol δ holoenzyme. Nat Commun 11: 1109.

Raducanu, V. S., Rashid, F., Zaher, M. S., Li, Y., Merzaban, J. S., Hamdan, S. M. (2020). A direct fluorescent signal transducer embedded in a DNA aptamer paves the way for versatile metal-ion detection. Sensors and Actuators B: Chemical. 304: 127376.

Kim, D., Rashid. F., Cho, Y,. Zaher, M.S., Cho, I.I.H., Hamdan, S.M., Jeong, C., Lee, J.B. (2019). DNA skybridge: 3D structure producing a light sheet for high-throughput single-molecule imagingNucleic Acids Research, 47 (18): e107.

Sobhy, M. A., Bralić, A., Raducanu, V. S., Tehseen, M., Ouyang, Y., Takahashi, M., Rashid, F., Zaher, M. S., Hamdan, S. M. (2019). Single-Molecule Förster Resonance Energy Transfer Methods for Real-Time Investigation of the Holliday Junction Resolution by GEN1. J. Vis. Exp. 151: e60045.

Kim, D., Rashid, F., Cho, Y., Zaher, M.S., Cho, I.I.H., Hamdan, S.M., Jeong, C., Lee, J.B. (2019). DNA skybridge: 3D structure producing a light sheet for high-throughput single-molecule imaging. Nucleic Acids Research. pii: gkz625.

Rashid, F.*, Raducanu, V.S.*, Zaher, M.S.*, Tehseen, M., Habuchi, S., Hamdan, S.M. (2019). Initial state of DNA-Dye complex sets the stage for protein induced fluorescence modulation. Nat Commun. 10 (1): 2104.

Sobhy, M.A., Bralić, A., Raducanu, V.S., Takahashi, M., Tehseen, M., Rashid, F., Zaher, M.S.*, Hamdan, S.M. (2019). Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level. Nucleic Acids Research. 47 (4): 1935-1949.

Zaher, M.S., Rashid, F.*, Song, B*., Joudeh, L.I., Sobhy, M.A., Tehseen, M., Hingorani, M.M., Hamdan, S.M. (2018). Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway. Nucleic Acids Research. 46 (6): 2956-2974.(* these authors contributed equally)

Rashid, F., Harris, P.D.*, Zaher, M.S.*, Sobhy, M.A., Joudeh, L.I., Yan, C., Piwonski, H., Tsutakawa, S.E., Ivanov, I., Tainer, J.A., Habuchi, S., Hamdan, S.M. (2017). Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1. eLife6: e21884.(* these authors contributed equally)

Zaher, M.S., Oke, M., Hamdan, S.M. (2014). Eukaryotic DNA Replicases. In Molecular Life Sciences: An Encyclopedic Reference, Ellis Bell, Judith S. Bond, Judith P. Klinman, Bettie Sue Siler Masters, Wells RD (eds). Berlin, Heidelberg: Springer-Verlag

Oke, M.,Zaher, M.S., Hamdan, S.M. (2014). Division of Labor. In Molecular Life Sciences: An Encyclopedic Reference, Bell E, Bond JS, Klinman JP, Masters BSS, Wells RD (eds). Berlin, Heidelberg: Springer-Verlag.

Oke, M.,Zaher, M.S., Hamdan, S.M. (2014). PCNA Structure and Interactions with Partner Proteins. In Molecular Life Sciences: An Encyclopedic Reference, Bell E, Bond JS, Klinman JP, Masters BSS, Wells RD (eds). Berlin, Heidelberg: Springer-Verlag.

Oke, M.,Zaher, M.S., Hamdan, S.M. (2014). Mechanism of PCNA loading by RFC. In Molecular Life Sciences: An Encyclopedic Reference, Bell E, Bond JS, Klinman JP, Masters BSS, Wells RD (eds). Berlin, Heidelberg: Springer-Verlag.

Ho, Y.S., Adroub, S.A., Aleisa, F., Mahmood, H., Othoum, G., Rashid, F., Zaher, M.S., Ali, S., Bitter, W., Pain, A., Abdallah, A.M. (2012). Complete Genome Sequence of Mycobacterium fortuitum subsp. Fortuitum Type Strain DSM46621. J. Bacteriol. 194 (22): 6337-6338.

Hobbies
Cooking, watching medical drama and crime shows, crafts.