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BBS student Olivia Sacco starts a rotation. Welcome Olivia!

BBS student Olivia Sacco starts a rotation. Welcome Olivia!

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Joyce accepts a job at Vertex. Congrats, Joyce! We will miss you!

Joyce accepts a job at Vertex. Congrats, Joyce! We will miss you!

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Updated Ruminations on AlphaFold Published

Johannes’ and others’ ruminations about AlphaFold are published: https://pubmed.ncbi.nlm.nih.gov/38306999/

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Ben Stinson’s Lig4 in NHEJ Paper is Accepted

Ben Stinson’s last paper on Lig4’s role in NHEJ is accepted. Look for it at https://rdcu.be/dyi84. Congrats, Ben!

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Predictomes Release Announcement

Graduate Student Ernst Schmid launches https://predictomes.org/, which leverages AlphaFold-Multimer to comprehensively explore protein-protein interactions in genome maintenance. Amazing work, Ernst!

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Donson story published in Science

Our paper describing the use of AlphaFold to discover how DONSON promotes replication initiation was published today.

https://www.science.org/doi/full/10.1126/science.adi3448

Congrats to Team DONSON (Yang, Ernst, Olga, Rhian) and thanks to our fabulous collaborators in the Andrew Jackson lab!

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Welcome Baby Florian!

Congratulations to Maksym and Natalia on the birth of their son Florian, and welcome to the world baby Florian!

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Maksym has received the William W. Wellington Memorial Research Fund Fellowship. Congratulations, Maksym!

Maksym has received the William W. Wellington Memorial Research Fund Fellowship.

Congratulations, Maksym!

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Pat Mannion joins the Walter lab as our new lab manager. Welcome, Patrick!

Pat Mannion joins the Walter lab as our new lab manager.

Welcome, Patrick!

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Jack Shaw and Helen Zhu are new undergraduates working in the lab. Welcome, Jack and Helen!

Jack Shaw and Helen Zhu are new undergraduates working in the lab.

Welcome, Jack and Helen!

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Ryan Grainger just joined the lab as a post-doc. Welcome, Ryan!

Ryan Grainger just joined the lab as a post-doc.

Welcome, Ryan!

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Congratulations to Ben Stinson

Ben has accepted an Assistant Professor position in the Dept. of Radiation Oncology at the Dana Farber Cancer Institute.

Congratulations and good luck, Ben!

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Tycho and Anisa’s paper on Trim-Away is now in press

Tycho and Anisa’s paper on Trim-Away is now in press. Check it out at: https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00136-5

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Justin’s last paper on DNA-protein cross-link (DPC) repair was just accepted at Mol Cell.

Justin’s last paper on DNA-protein cross-link (DPC) repair was just accepted at Mol Cell. It shows that the ATPase FANCJ unfolds the DPC in preparation for proteolysis. Congrats, Justin (in absentia)! Thanks to our amazing collaborators Julian Stingele, Denitsa Yaneva, and Max Donsbach, who helped make it happen.

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Post-doc Alex Wu has accepted a position at Arrakis Therapeutics. Best of luck, Alex!

Post-doc Alex Wu has accepted a position at Arrakis Therapeutics.

Best of luck, Alex!

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Olga’s paper showing how UBXN7 cooperates with p97 to facilitate CMG disassembly during replication termination is published in Nature Communications! Congratulations Olga!

Olga’s paper showing how UBXN7 cooperates with p97 to facilitate CMG disassembly during replication termination is published in Nature Communications! Congratulations Olga! Read the full story here: Cooperative assembly of p97 complexes involved in replication termination

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Rhian Gruar joining

The lab welcomes visiting scholar Rhian Gruar who is joining us to work with Manal for the next few months!

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Md-PhD student Martha Longley has joined the Walter lab. Welcome, Martha!

MD-PhD student Martha Longley has joined the Walter lab. Welcome, Martha!

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Tycho and Anissa in the lab have established the targeted protein degradation method Trim-Away in frog egg extracts and shown that the underlying mechanism is different from what was previously proposed.

Tycho and Anissa in the lab have established the targeted protein degradation method Trim-Away in frog egg extracts and shown that the underlying mechanism is different from what was previously proposed. https://www.biorxiv.org/content/10.1101/2022.07.23.501259v1

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Welcome to Giselle Chiprez

Welcome to undergraduate Giselle Chiprez who is joining us to work with Maksym!

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Ben and Izarys have a baby girl. Welcome, Isabela!

Ben and Izarys have a baby girl. Welcome, Isabela!

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Joyce is awarded an HHMI Jane-Coffin Childs post-doctoral fellowship. Congratulations, Joyce!

Joyce is awarded an HHMI Jane-Coffin Childs post-doctoral fellowship. Congratulations, Joyce!

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Ernst receives the NSF Graduate Research Fellowship. Congrats, Ernst!

Ernst receives the NSF Graduate Research Fellowship. Congrats, Ernst!

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Robert Dilley accepts a post-doctoral position in the Walter lab. He will join after completion of his clinical training in 2024. Looking forward to see you then, Robert!

Robert Dilley accepts a post-doctoral position in the Walter lab. He will join after completion of his clinical training in 2024. Looking forward to see you then, Robert!

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Former post-doc Dan Semlow’s paper (https://www.biorxiv.org/content/10.1101/2021.07.29.454365v1?ct=ct) on HMCES and its role in ICL repair is now in press at NSMB. Congrats, Dan!

Former post-doc Dan Semlow’s paper (https://www.biorxiv.org/content/10.1101/2021.07.29.454365v1?ct=ct) on HMCES and its role in ICL repair is now in press at NSMB. Congrats, Dan!

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G1 BBS student Liam Healy starts his rotation. Welcome Liam!

G1 BBS student Liam Healy starts his rotation. Welcome Liam!

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Mimi Kay joins the Walter lab as our new lab manager. Welcome, Mimi!

Mimi Kay joins the Walter lab as our new lab manager. Welcome, Mimi!

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Welcome to MD/PhD student Martha Longley who will do a rotation with us.

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Kyle accepts a position at New England Biolabs. Congrats, Kyle! We are thrilled you will remain local. (free EcoRI for us?)

Kyle accepts a position at New England Biolabs. Congrats, Kyle, and we are thrilled you will stay local!

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BBS graduate student Ernst Schmid joins the lab. Welcome Ernst!

BBS graduate student Ernst Schmid joins the lab. Welcome Ernst!

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Welcome to Jesse Pellman, who is doing a summer internship with us.

Welcome to Jesse Pellman, who is doing a summer internship with us.

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Anisa is finally able to start working in person. Welcome Anisa!

Anisa is finally able to start working in person. Welcome Anisa!

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Congrats to Justin for starting a biologist position with the US air force!

Congrats to Justin for starting a biologist position with the US air force!

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Alex is awarded a K99 path to independence fellowship. Congratulations, Alex!

Alex is awarded a K99 path to independence fellowship. Congratulations, Alex!

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Megan and Justin have a baby girl. Welcome, Chloe!

Megan and Justin have a baby girl. Welcome, Chloe!

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Maksym Shyian joins the lab as a post-doctoral fellow and has already procured a fellowship from the Swiss National Science Foundation. Welcome and congrats, Maksym!

Maksym Shyian joins the lab as a post-doctoral fellow and has already procured a fellowship from the Swiss National Science Foundation. Welcome and congrats, Maksym!

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Kyle’s paper showing that CMG dissociates at nicks in the leading and lagging strand templates is now in press at Molecular Cell. Congratulations Kyle, and thanks to all who contributed!

Kyle’s paper showing that CMG dissociates at nicks in the leading and lagging strand templates is now in press at Molecular Cell. Congratulations Kyle, and thanks to all who contributed!

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Our latest paper on replication termination is published online in Genes&Development. Single molecule and ensemble studies support an unexpected mechanism that triggers CMG unloading upon termination. Great job Emily, Gheorghe, Manal, and Olga!

Our latest paper on replication termination is published online in Genes&Development. Single molecule and ensemble studies support an unexpected mechanism that triggers CMG unloading upon termination. Great job Emily, Gheorghe, Manal, and Olga!

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Ravi will join Vor Biopharma in September. Congrats, Ravi!

Ravi will join Vor Biopharma in September. Congrats, Ravi!

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Lin starts his own group at Shenzhen Bay Laboratory in Guangdong, China. Congrats, Lin!

Lin starts his own group at Shenzhen Bay Laboratory in Guangdong, China. Congrats, Lin!

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Brandon and Jun have a baby girl named Ellie. Congratulations!

Brandon and Jun have a baby girl named Ellie. Congratulations!

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Alex and Vanessa get married. Congratulations!

Alex and Vanessa get married. Congratulations!

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Manal is awarded a Prince Alwaleed Bin Talal post-doctoral Fellowship. Congratulations, Manal!

Manal is awarded a Prince Alwaleed Bin Talal post-doctoral Fellowship. Congratulations, Manal!

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Lab Alumnus Emily Low starts her new job at Nurix Therapeutics. Good luck Emily!

Lab Alumnus Emily Low starts her new job at Nurix Therapeutics. Good luck Emily!

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Geylani receives the AACR-Cancer Research UK Transatlantic Early Career Development Fellowship. Congratulations, Geylani!

Geylani receives the AACR-Cancer Research UK Transatlantic Early Career Development Fellowship. Congratulations, Geylani!

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Ben Stinson is awarded a Dale Frey Award for Breakthrough Scientists. Congratulations, Ben!

Ben Stinson is awarded a Dale Frey Award for Breakthrough Scientists. Congratulations, Ben!

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Brandon Case joins the lab as a post-doctoral fellow. Welcome Brandon!

Brandon Case joins the lab as a post-doctoral fellow. Welcome Brandon!

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Manal Zaher joins the lab as a post-doctoral fellow. Welcome Manal!

Manal Zaher joins the lab as a post-doctoral fellow. Welcome Manal!

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BBS graduate student Yang Lim joins the lab. Welcome Yang!

BBS graduate student Yang Lim joins the lab. Welcome Yang!

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Gheorghe accepts an Assistant Professor position at Stanford. Congrats Gheorghe!

Gheorghe accepts an Assistant Professor position at Stanford. Congrats Gheorghe!

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Dan Semlow accepts an Assistant Professor Position at Caltech. Congrats, Dan!

Dan Semlow accepts an Assistant Professor Position at Caltech. Congrats, Dan!

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Geylani Can joins the lab as a post-doctoral fellow

Geylani Can joins the lab as a post-doctoral fellow

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Justin Sparks is awarded a Dale Frey Award for Breakthrough Scientists

Justin Sparks is awarded a Dale Frey Award for Breakthrough Scientists

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Lin and Weiping welcome their baby girl Ivy!

Lin and Weiping welcome their baby girl Ivy!

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Justin and Megan’s baby girl Naomi arrives!

Justin and Megan’s baby girl Naomi arrives!

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Dan Semlow has been granted an NIH K99 award

Dan Semlow has been granted an NIH K99 award

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Gheorghe and Liem’s baby Henry was born

Gheorghe and Liem’s baby Henry was born

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Alex Wu has been awarded an American Cancer Society Postdoctoral Fellowship

Alex Wu has been awarded an American Cancer Society Postdoctoral Fellowship

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Johannes is now an American Cancer Society Research Professor

Johannes is now an American Cancer Society Research Professor

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