What do we study?

Before they divide, vertebrate cells copy six billion base pairs of DNA with almost perfect fidelity. We study how they accomplish this amazing feat. We ask how replication machines are assembled and disassembled at the appropriate time and place, and how they overcome obstacles and DNA lesions in the template strands. Our work sheds light on the etiology of cancer and other diseases.

What’s our approach?

We use Xenopus laevis frog egg extracts, which recapitulate essentially all aspects of genome maintenance and are therefore like a “cell in a test tube.” Using this highly tractable system in combination with classical biochemistry, single molecule imaging, and cell-based studies, we have discovered new DNA replication and repair mechanisms, many of which are mutated in human diseases (see Research).

Why join the Walter Lab?

The Walter laboratory is a welcoming and highly interactive environment. Graduate students and post-doctoral fellows share reagents, expertise, and ideas to reach their common goal of understanding genome maintenance in health and disease. Walter lab alumni are successful in obtaining group leader, post-doctoral, industry, and other positions (see alumni). Post-docs who start their own groups are free to take their projects with them.

News

Welcome to MD/PhD student Martha Longley who will do a rotation with us.

News

Kyle accepts a position at New England Biolabs. Congrats, Kyle! We are thrilled you will remain local. (free EcoRI for us?)

Kyle accepts a position at New England Biolabs. Congrats, Kyle, and we are thrilled you will stay local!

News

BBS graduate student Ernst Schmid joins the lab. Welcome Ernst!

BBS graduate student Ernst Schmid joins the lab. Welcome Ernst!

News

Welcome to Jesse Pellman, who is doing a summer internship with us.

Welcome to Jesse Pellman, who is doing a summer internship with us.

News