What do we study?

Before they divide, vertebrate cells copy six billion base pairs of DNA with almost perfect fidelity. We study how they accomplish this amazing feat. We ask how replication machines are assembled and disassembled at the appropriate time and place, and how they overcome DNA damage and other obstacles. Our work sheds light on the etiology of diseases such as cancer, bone marrow failure, aging, and neurodegeneration.

What’s our approach?

We use Xenopus laevis frog egg extracts, which recapitulate essentially all aspects of genome maintenance and are therefore like a “cell in a test tube.” Using this highly tractable system in combination with classical biochemistry, single molecule imaging, and cell-based studies, we have discovered new DNA replication and repair mechanisms, many of which are mutated in human diseases (see Research).

Why join the Walter Lab?

The Walter laboratory is a welcoming and highly interactive environment. Graduate students and post-doctoral fellows share reagents, expertise, and ideas to reach their common goal of understanding genome maintenance in health and disease. Walter lab alumni are successful in obtaining group leader, post-doctoral, industry, and other positions (see alumni). Post-docs who start their own groups are free to take their projects with them.


Predictomes Release Announcement

Graduate Student Ernst Schmid launches https://predictomes.org/, which leverages AlphaFold-Multimer to comprehensively explore protein-protein interactions in genome maintenance. Amazing work, Ernst!


Donson story published in Science

Our paper describing the use of AlphaFold to discover how DONSON promotes replication initiation was published today.


Congrats to Team DONSON (Yang, Ernst, Olga, Rhian) and thanks to our fabulous collaborators in the Andrew Jackson lab!


Welcome Baby Florian!

Congratulations to Maksym and Natalia on the birth of their son Florian, and welcome to the world baby Florian!


Maksym has received the William W. Wellington Memorial Research Fund Fellowship. Congratulations, Maksym!

Maksym has received the William W. Wellington Memorial Research Fund Fellowship.

Congratulations, Maksym!