Tycho Mevissen

Post-doc

617-432-2927

Education
2008-2012 Diploma (equivalent to M.Sc.) Biochemistry Freie Universität Berlin, Germany
2012-2016 Ph.D. Biochemistry University of Cambridge and MRC Laboratory of Molecular Biology, Cambridge, UK (supervisor: David Komander)
2016-Present Postdoctoral fellow Harvard Medical School
(supervisor, Johannes Walter)
Awards and Honors
2011 Erasmus grant for an internship at the MRC LMB, Cambridge, UK
2011 DAAD-ACS-IREU Scholarship for an internship at Vanderbilt University, Nashville, TN, USA
2012-2015 Marie Curie Fellowship, Initial Training Network (ITN) UPStream
2013 GBM Diploma-/Masterprize of the German Society for Biochemistry and Molecular Biology
2016 Rainer Rudolph PhD Award, Rainer Rudolph Foundation, DE
2016 Max Perutz Student Prize, MRC LMB, Cambridge, UK
2017 EMBO Long-Term Fellowship
2017 Karl Lohmann PhD Award by the German Society for Biochemistry and Molecular Biology
2018-2020 HHMI Fellowship of The Jane Coffin Childs Memorial Fund for Medical Research

Publications
van der Weegen, Y., de Lint, K., van den Heuvel, D., Nakazawa, Y., Mevissen, T.E.T., van Schie, J.J.M., San Martin Alonso, M., Boer, D.E.C., González-Prieto, R., Narayanan, I.V., Klaassen, N.H.M., Wondergem, A.P., Roohollahi, K., Dorsman, J.C., Hara, Y., Vertegaal, A.C.O., de Lange, J., Walter, J.C., Noordermeer, S.M., Ljungman, M., Ogi, T., Wolthuis, R.M.F. & Luijsterburg, M.S. (2021). ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation. Nature Cell Biol. 23(6): 595–607.

Spagnol, V., Oliveira, C.A.B., Randle, S.J., Passos, P.M.S., Correia, C.R.S.T.B., Simaroli, N.B., Oliveira, J.S., Mevissen, T.E.T., Medeiros, A.C., Gomes, M.D., Komander, D., Laman, H. & Teixeira, F.R. (2021). The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway. BBA – General Subjects 1865(1): 129754.

van der Weegen, Y., Golan-Berman, H., Mevissen, T.E.T., Apelt, K., González-Prieto, R., Goedhart, J., Heilbrun, E.E., Vertegaal, A.C.O., van den Heuvel, D., Walter, J.C., Adar, S. & Luijsterburg, M.S. (2020). The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II. Nat. Commun. 11: 2104.

Swatek, K.N., Usher, J.L., Kueck, A.F., Gladkova, C., Mevissen, T.E.T., Pruneda, J.N., Skern, T. & Komander, D. (2019). Insights into ubiquitin chain architecture using Ub-clipping. Nature 572: 533–7.

Mevissen, T.E.T. & Komander, D. (2017). Mechanisms of Deubiquitinase Specificity and Regulation. Annu. Rev. Biochem. 86: 159–92

Mevissen, T.E.T., Kulathu, Y.*, Mulder, M.P.C.*, Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H. & Komander, D. (2016). Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature538: 402–405
(* these authors contributed equally)

Teixeira, F.R.*, Randle, S.J.*, Patel, S.P.*, Mevissen, T.E.T., Zenkeviciute, G., Koide, T., Komander, D. & Laman, H. (2016). Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson’s disease. Biochem. J. 473: 3563–3580.
(* these authors contributed equally)

Flierman, D.*, van der Heden van Noort, G.J.*, Ekkebus, R.*, Geurink, P.P., Mevissen, T.E.T., Hospenthal, M.K., Komander, D. & Ovaa, H. (2016). Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem. Biol. 23: 472–82
(* these authors contributed equally)

Geurink, P.P., van Tol, B.D.M., van Dalen, D., Brundel, P.J.G., Mevissen, T.E.T., Pruneda, J.N., Elliott, P.R., van Tilburg, G.B.A., Komander, D. & Ovaa, H. (2016). Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes. ChemBioChem. 17: 816–20.

Min, M., Mevissen, T.E.T., De Luca, M., Komander, D. & Lindon, C. (2015). Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell. 26: 4325–32.

Hospenthal, M.K.*, Mevissen, T.E.T.* & Komander, D. (2015). Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest). Nat. Protoc. 10: 349–61.
(* these authors contributed equally)

Birsa, N., Norkett, R., Wauer, T., Mevissen, T.E.T., Wu, H.C., Foltynie, T., Bhatia, K., Hirst, W.D., Komander, D., Plun-Favreau, H. & Kittler, J.T. (2014). K27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J. Biol. Chem. 289: 14569–82.

Mevissen, T.E.T., Hospenthal, M.K.*, Geurink, P.P.*, Elliott, P.R.*, Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H. & Komander, D. (2013). OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis. Cell 154: 169–84.
(* these authors contributed equally)

Kulathu, Y., Garcia, F.J., Mevissen, T.E.T., Busch, M., Arnaudo, N., Carroll, K.S., Barford, D. & Komander, D. (2013). Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat. Commun. 4: 1569.

Licchesi, J.D.F., Mieszczanek, J., Mevissen, T.E.T., Rutherford, T.J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J.W., Ovaa, H., Bienz, M. & Komander, D. (2012). An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat. Struct. Mol. Biol. 19: 62–71.