Publications

Vrtis, K. B., Dewar, J. M., Chistol, G., Wu, R. A., Graham, T. G., Walter, J. C. (2021). Single-strand DNA breaks cause replisome disassembly. Mol Cell. 81(6): 1309-1318.

Wu, R.A., Pellman, D.S., Walter, J.C. (2021). The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome. Trends Cell Biol. 31(2): 75-85.

Wang, A.S., Chen, L.C., Wu, R.A., Hao, Y., McSwiggen, D.T., Heckert, A.B., Richardson, C.D., Gowin, B.G., Kazane, K.R., Vu, J.T., Wyman, S.K., Shin, J.J., Darzacq, X., Walter, J.C., Corn, J.E. (2020). The Histone Chaperone FACT Induces Cas9 Multi-Turnover Behavior and Modifies Genome Manipulation in Human Cells. Mol Cell. 79(2): 221-233.e5.

Deng, L., Wu, R.A. , Sonneville, R., Kochenova, O.V., Labib, K., Pellman, D., Walter, J.C (2019). Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements. Mol Cell. 73(5): 915-929.

Wu, R.A. , Semlow, D.R., Kamimae-Lanning, A.N., Kochenova, O.V., Chistol, G., Hodskinson, M.R., Amunugama, R., Sparks, J.L., Wang, M., Deng, L., Mimoso, C.A., Low, E., Patel, K.J., Walter, J.C. (2019). TRAIP is a master regulator of DNA interstrand crosslink repair. Nature. doi:10.1038/s41586-019-1002-0.

Larsen N.B., Gao A.O., Sparks J.L., Gallina I., Wu R.A. , Mann M., Räschle M., Walter J.C., Duxin J.P. (2019). Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts. Mol Cell. 73: 1-15.

Amunugama, R., Willcox, S., Wu, R.A., Abdullah, U.B., El-Sagheer, A.H., Brown, T., McHugh, P.J., Griffith, J.D., Walter, J.C. (2018). Replication fork reversal during DNA interstrand crosslink repair requires CMG unloading. Cell Rep. 23(2): 3419-3428.

Nguyen, T.H.D., Tam, J., Wu, R.A., Gerber, B.J., Toso, D., Nogales, E., Collins, K. (2018). Cryo-EM structure of substrate-bound human telomerase holoenzyme. Nature. 557(7704): 190-195.

Wu, R.A., Tam, J., Collins, K. (2017). DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity. EMBO J. 36(13): 1908-1927.

Wu, R.A., Upton, H.E., Vogan, J.M., Collins, K. (2017). Telomerase mechanism of telomere synthesis. Annu Rev Biochem. 86: 439-460.

Chiba, K., Vogan, J.M., Wu, R.A., Gill, M.S., Zhang, X., Collins, K., Hockemeyer, D. (2017). Endogenous telomerase reverse transcriptase N-terminal tagging affects human telomerase function at telomeres in vivo. Mol Cell Biol. 37(3): pii: e00541-16.

Wu, R.A., Dagdas, Y.S., Yilmaz, S.T., Yildiz, A., Collins, K. (2015). Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes. eLife. 4: e08363.

Wu, R.A., Collins, K. (2014). Sequence specificity of human telomerase. Proc Natl Acad Sci USA. 111(31): 11234-11235.

Wu, R.A., Collins, K. (2014). Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex. EMBO J. 33(8): 921-935

Trobridge, G.D., Beard, B.C., Wu, R.A., Ironside, C., Malik, P., Kiem, H.P. (2012). Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency. PLoS One. 7(9): e45173.

Trobridge, G.D., Wu, R.A., Hansen, M., Ironside, C., Watts, K.L., Olsen, P., Beard, B.C., Kiem, H.P. (2010). Cocal-pseudotyped lentiviral vectors resist inactivation by human serum and efficiently transduce primate hematopoietic repopulating cells. Mol Ther. 18(4): 725-733.

Kiem, H.P., Wu, R.A., Sun, G., von Laer, D., Rossi, J.J., Trobridge, G.D. (2010). Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo. Gene Ther. 17(1): 37-49.

Trobridge, G.D., Wu R.A., Beard, B.C., Chiu, S.Y., Munoz, N.M., von Laer, D., Rossi, J.J., Kiem, H.P. (2009). Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection. PLoS One. 4(11): e7693.