Martha Longley

MD/PhD Student



2014-2018 B.S. Biochemistry Yale University
2020-Present MD/PhD student Harvard/MIT Harvard Medical School (supervisor: Johannes Walter)

Awards and honors

Magna Cum Laude (Yale University)
Phi Beta Kappa (Yale University)
Pat Wilde Prize (Yale University)
Intramural Research Training Award (NIH)


Longley, J. Lee, J. Jung, F.W. Lohoff, Epigenetics of Alcohol Use Disorders – A Review of Recent Advances in Methylation Profiling,Addiction Biology,2021. doi: 10.1111/adb.13006.

F.W. Lohoff, A. Roy, J. Jung, M. Longley, D. Rosoff, A. Luo, E. O’Connell, J. Sorcher, H. Sun, M. Schwandt, C. Hodgkinson, D. Goldman, R. Momenan, A. McIntosh, M. Adams, R. Walker, K. Evans, A. Murray, D. Porteous, A. Smith, J. Lee, C. Muench, K. Charlet, T. Clarke, Z. Kaminsky, Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation, Molecular Psychiatry, 2020. doi: 10.1038/s41380-020-0734-4.

Luo*, J. Jung*,M. Longley, D.B. Rosoff, K. Charlet, C. Muench, J. Lee, C. Hodgkinson, Z.A. Kaminsky, F.W. Lohoff, DNA methylation age and GWAS of epigenetic aging rates in AUD reveals a role for APOL2,Neuropsychopharmacology, 2020, 45(2):327-336. doi: 10.1038/s41386-019-0500-y. *equal contribution

Cole, N. Planavsky,M. Longley, P. Boning, D. Wilkes, X. Wang, E. Swanner, C. Wittkop, V. Busigny, A. Knudsen, E. Sperling, Uranium isotope fractionation in anoxic settings and the global uranium isotope mass balance,Global Biogeochemical Cycles, 2020. doi: 10.1029/2020GB006649

D.B. Rosoff*, K. Charlet*, J. Jung, J. Lee, C. Muench, A. Luo, M. Longley, F.W. Lohoff, Lipid profile dysregulation predicts alcohol withdrawal symptom severity in individuals with alcohol use disorder, Alcohol, 2020, S0741-8329(20)30178-6. doi:10.1016/j.alcohoo.2020.02.164 *equal contribution

Jung*, D.B. Rosoff*, C. Muench, A. Luo,M. Longley, J. Lee, K. Charlet, F.W. Lohoff, Adverse childhood experiences are associated with high-intensity binge drinking behavior in adulthood and mediated by psychiatric disorders,Alcohol and Alcoholism, 2020, 55(2):204-214. doi: 10.1093/alcalc/agz098. *equal contribution

D.B. Rosoff, K. Charlet, J. Jung, J. Lee, C. Muench, A. Luo, M. Longley, K.L. Mauro, F.W. Lohoff, Association of high-intensity binge drinking with lipid and liver function enzyme levels, JAMA Network Open, 2019, 20192

Lee, D.B. Rosoff, A. Luo,M. Longley, M. Phillips, K. Charlet, C. Muench, J. Jung, F.W. Lohoff, PCSK9 is increased in cerebrospinal fluid of individuals with alcohol use disorder,Alcoholism: Clinical and Experimental Research, 2019, 43:1163-1169.