Robert Dilley

Post-doc

617-432-2927

Education
2008-2011 B.S. Cell and Molecular Biology Johns Hopkins University
2012-2018 Ph.D. Cell and Molecular Biology University of Pennsylvania (supervisor: Roger Greenberg)
2012-2021 M.D. University of Pennsylvania
2021-2023 Internal Medicine Resident Massachusetts General Hospital
2023-present Oncology Fellow Dana-Farber Cancer Institute
2024-Present Postdoctoral fellow Harvard Medical School (supervisor, Johannes Walter)
Awards and honors
2011 Phi Beta Kappa
2019 Saul Winegrad Award for Outstanding Dissertation, University of Pennsylvania
2021 Alpha Omega Alpha
2021 Emily and Francis Botelho Prize for Excellence in Basic Science, University of Pennsylvania
2021 The Michael S. Brown M.D. Award, University of Pennsylvania
Publications

Krishnamoorthy V, Foglizzo M, Dilley RL, Wu A, Datta A, Dutta P, Campbell LJ, Degtjarik O, Musgrove LJ, Calabrese AN, Zeqiraj E, Greenberg RA. The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity. Cell. 2024 Apr 25; 187(9): 2250-2268.e31. doi: 10.1016/j.cell.2024.03.002.

Zhang H, Zhao R, Tones J, Liu M, Dilley RL, Chenoweth DM, Greenberg RA, Lampson MA. Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020 Aug 15; 31(18): 2048-2056. doi: 10.1091/mbc.E19-10-0589.

Poh W, Dilley RL, Moliterno AR, Maciejewski JP, Pratz KW, McDevitt MA, Herman JG. BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloid Malignancies. Clin Cancer Res. 2019 Apr 15; 25(8): 2513-2522. doi: 10.1158/1078-0432.CCR-18-0179.

Verma P, Dilley RL, Zhang T, Gyparaki MT, Li Y, Greenberg RA. RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening. Genes Dev. 2019 Feb 1; 33(3-4): 221-235. doi: 10.1101/gad.319723.118.

Verma P, Dilley RL, Gyparaki MT, Greenberg RA. Direct Quantitative Monitoring of Homology-Directed DNA Repair of Damaged Telomeres. Methods Enzymol. 2018; 600: 107-134. doi: 10.1016/bs.mie.2017.11.010.

Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, Greenberg RA. Break-induced telomere synthesis underlies alternative telomere maintenance. Nature. 2016 Nov 3; 539(7627): 54-58. doi: 10.1038/nature20099.

Pratz KW, Koh BD, Patel AG, Flatten KS, Poh W, Herman JG, Dilley R, Harrell MI, Smith BD, Karp JE, Swisher EM, McDevitt MA, Kaufmann SH. Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms. Clin Cancer Res. 2016 Aug 1; 22(15): 3894-902. doi: 10.1158/1078-0432.CCR-15-2351.

Dilley RL, Greenberg RA. ALTernative Telomere Maintenance and Cancer. Trends Cancer. 2015 Oct 1; 1(2): 145-156. doi: 10.1016/j.trecan.2015.07.007.

Cho NW, Dilley RL, Lampson MA, Greenberg RA. Interchromosomal homology searches drive directional ALT telomere movement and synapsis. Cell. 2014 Sep 25; 159(1): 108-121. doi: 10.1016/j.cell.2014.08.030.

Dilley RL, Poh W, Gladstone DE, Herman JG, Showel MM, Karp JE, McDevitt MA, Pratz KW. Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro. Leuk Res. 2014 Mar; 38(3): 411-7. doi: 10.1016/j.leukres.2013.12.019.

Hobbies
Mountain biking, exploring new places, crime shows/books