Smriti Pandey

Post-doc


617-432-2927

Education
2015-2019 B.A. Biochemistry Mount Holyoke College (supervisor, Katherine E. Berry)
2019-2024 Ph.D. Biology and Biomedical Sciences Harvard University (supervisor, David R. Liu)
Awards and honors
2018 Louisa Stone Stevenson Prize for Excellence in Chemistry (Mount Holyoke College)
2019 Gertrude “Bobby” Lerch Award in Biochemistry (Mount Holyoke College)
2019 Phi Beta Kappa (Mount Holyoke College)
2024 Stuart L. Schreiber prize in Scientific Excellence for Graduate Students (Broad Institute)
2024 Forbes 30 under 30 Healthcare, Class of 2025, North America

Publications

Tao, Y.A.*; Sakai, H.A.*; Jiang, A.Y.*; Krasnow, N.A.*; Vaganov, V.S.; Shim, B.; Barsdale, Z.; Ahmed, N.; Na, M.; Pandey, S.; Cristian, A.; Zhang, E.; Xu, J.A.; Bulcaen, M.; Liu, D.R. “AI-guided re-design of laboratory-evolved reverse transcriptases enhances prime editing in human cells and in animals.” Nature Biotechnology (2026).

Hsu, A.*; Chen, P.J.*; Li, A.H.*; Hemez, C., Gao, X.D.; Terry, M.; Nelson, C.; Selvam, V.; Christian, A.; McElroy, A.; Steinbeck, B.J.; Mahadeshwar, G.K.; Pandey S.; Barsdale, Z.; Chen, P.Z.; Sousa, A.A.; Sakai, H.A.; Silverstein, R.A.; Morad, I.; Krueger, R.K.; Shen, M.W.; Kleinsteiver, B.P.; Lutz, C.M.; Tolar, J.; Blazar, B.R.; Osborn, M.J.; Liu, D.R. “Mechanistic machine learning enables interpretable and generalizable prediction of prime editing.” Nature Biotechnology (2026).

Sousa, A.A.*; Hemez, C.*; Lei, L.; Traore, S.; Kulhankova, K.; Newby, G.A.; Doman, J.L.; Oye, K.; Pandey, S.; Karp, P.H.; McCray, P.B.; Liu, D.R. “Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells” Nature Biomedical Engineering (2024).

Pandey S.*; Gao, X.D.*; Krasnow, N.; McElroy, A.; Tao, Y.A.; Duby, J.E.; Steinbeck, B.J.; McCreary, J.; Pierce, S.E.; Tolar, J.; Meissner, T.B.; Chaikof, E.L.; Osborn, M.J.; Liu, D.R. “Efficient and versatile programmable large-gene integration in mammalian cells enabled by continuously evolved recombinases and prime editing” Nature Biomedical Engineering (2024).

Steinbeck, B.J.*; Gao, X.D.*; McElroy, A.N.; Pandey, S.; Doman, J.L.; Riddle, M.J.; Xia, L.; Chen, W.; Eide, C.R.; Lengert, A.H.; Han, S.W.; Blazar, B.R.; Wandall, H.H.; Dabelsteen, S.; Liu, D.R.; Tolar, J.; Osborn, M.J. “Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa” Journal of Investigative Dermatology (2024).

Doman, J.L.*; Pandey, S.*; Neugebauer, M.E.; An, M.; Davis, J.R.; Randolph, P.B.; McElroy, A.; Gao, X.D.; Raguram, A.; Richter, M.F.; Everette, K.E.; Banskota, S.; Tian, K.; Tao, Y.A.; Tolar, J.; Osborn, M.J.; Liu, D.R. “Phage-assisted evolution and protein engineering yield compact, efficient prime editors” Cell 186, 3983-4002 e3926 (2023).

Neugebauer, M. E.; Hsu, A., Arbab, M.; Krasnow, N. A.; Pandey, S.; Doman, J. L.; McElroy, A. N.; Huang, T. P.; Raguram, A.; Banskota, S.; Newby, G. A.; Tolar, J.; Osborn, M. J.; Liu, D. R. “Evolution of an Adenine Base Editor into a Small, Efficient Cytosine Base Editor with Low Off-Target Activity” Nature Biotechnology41, 673–685 (2023).

Pandey, S.; Gravel, G.M.; Stockert, O.M.; Wang, C.D.; Hegner, C.L.; LeBlanc, H., Berry, K.E. “Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ” Nucleic Acids Research 48, 8, 4507-4520 (2020).

Hobbies

Cooking, walking, watching TV