Tycho Mevissen
| 2008-2012 | Diploma (equivalent to M.Sc.) Biochemistry | Freie Universität Berlin, Germany |
| 2012-2016 | Ph.D. Biochemistry | University of Cambridge and MRC Laboratory of Molecular Biology, Cambridge, UK (supervisor: David Komander) |
| 2016-Present | Postdoctoral fellow | Harvard Medical School (supervisor, Johannes Walter) |
| 2011 | Erasmus grant for an internship at the MRC LMB, Cambridge, UK |
| 2011 | DAAD-ACS-IREU Scholarship for an internship at Vanderbilt University, Nashville, TN, USA |
| 2012-2015 | Marie Curie Fellowship, Initial Training Network (ITN) UPStream |
| 2013 | GBM Diploma-/Masterprize of the German Society for Biochemistry and Molecular Biology |
| 2016 | Rainer Rudolph PhD Award, Rainer Rudolph Foundation, DE |
| 2016 | Max Perutz Student Prize, MRC LMB, Cambridge, UK |
| 2017 | EMBO Long-Term Fellowship |
| 2017 | Karl Lohmann PhD Award by the German Society for Biochemistry and Molecular Biology |
| 2018-2020 | HHMI Fellowship of The Jane Coffin Childs Memorial Fund for Medical Research |
Publications 
Mevissen TET, Prasad AV, Walter JC. TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away. Cell Rep. 2023 Feb 18;42(2):112125. doi: 10.1016/j.celrep.2023.112125.
van der Weegen, Y., de Lint, K., van den Heuvel, D., Nakazawa, Y., Mevissen, T.E.T., van Schie, J.J.M., San Martin Alonso, M., Boer, D.E.C., González-Prieto, R., Narayanan, I.V., Klaassen, N.H.M., Wondergem, A.P., Roohollahi, K., Dorsman, J.C., Hara, Y., Vertegaal, A.C.O., de Lange, J., Walter, J.C., Noordermeer, S.M., Ljungman, M., Ogi, T., Wolthuis, R.M.F. & Luijsterburg, M.S. (2021). ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation. Nature Cell Biol. 23(6): 595–607.
Spagnol, V., Oliveira, C.A.B., Randle, S.J., Passos, P.M.S., Correia, C.R.S.T.B., Simaroli, N.B., Oliveira, J.S., Mevissen, T.E.T., Medeiros, A.C., Gomes, M.D., Komander, D., Laman, H. & Teixeira, F.R. (2021). The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway. BBA – General Subjects 1865(1): 129754.
van der Weegen, Y., Golan-Berman, H., Mevissen, T.E.T., Apelt, K., González-Prieto, R., Goedhart, J., Heilbrun, E.E., Vertegaal, A.C.O., van den Heuvel, D., Walter, J.C., Adar, S. & Luijsterburg, M.S. (2020). The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II. Nat. Commun. 11: 2104.
Swatek, K.N., Usher, J.L., Kueck, A.F., Gladkova, C., Mevissen, T.E.T., Pruneda, J.N., Skern, T. & Komander, D. (2019). Insights into ubiquitin chain architecture using Ub-clipping. Nature 572: 533–7.
Mevissen, T.E.T. & Komander, D. (2017). Mechanisms of Deubiquitinase Specificity and Regulation. Annu. Rev. Biochem. 86: 159–92
Mevissen, T.E.T., Kulathu, Y.*, Mulder, M.P.C.*, Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H. & Komander, D. (2016). Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature. 538: 402–405
(* these authors contributed equally)
Teixeira, F.R.*, Randle, S.J.*, Patel, S.P.*, Mevissen, T.E.T., Zenkeviciute, G., Koide, T., Komander, D. & Laman, H. (2016). Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson’s disease. Biochem. J. 473: 3563–3580.
(* these authors contributed equally)
Flierman, D.*, van der Heden van Noort, G.J.*, Ekkebus, R.*, Geurink, P.P., Mevissen, T.E.T., Hospenthal, M.K., Komander, D. & Ovaa, H. (2016). Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem. Biol. 23: 472–82
(* these authors contributed equally)
Geurink, P.P., van Tol, B.D.M., van Dalen, D., Brundel, P.J.G., Mevissen, T.E.T., Pruneda, J.N., Elliott, P.R., van Tilburg, G.B.A., Komander, D. & Ovaa, H. (2016). Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes. ChemBioChem. 17: 816–20.
Min, M., Mevissen, T.E.T., De Luca, M., Komander, D. & Lindon, C. (2015). Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages. Mol. Biol. Cell. 26: 4325–32.
Hospenthal, M.K.*, Mevissen, T.E.T.* & Komander, D. (2015). Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest). Nat. Protoc. 10: 349–61.
(* these authors contributed equally)
Birsa, N., Norkett, R., Wauer, T., Mevissen, T.E.T., Wu, H.C., Foltynie, T., Bhatia, K., Hirst, W.D., Komander, D., Plun-Favreau, H. & Kittler, J.T. (2014). K27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J. Biol. Chem. 289: 14569–82.
Mevissen, T.E.T., Hospenthal, M.K.*, Geurink, P.P.*, Elliott, P.R.*, Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H. & Komander, D. (2013). OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis. Cell 154: 169–84.
(* these authors contributed equally)
Kulathu, Y., Garcia, F.J., Mevissen, T.E.T., Busch, M., Arnaudo, N., Carroll, K.S., Barford, D. & Komander, D. (2013). Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat. Commun. 4: 1569.
Licchesi, J.D.F., Mieszczanek, J., Mevissen, T.E.T., Rutherford, T.J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J.W., Ovaa, H., Bienz, M. & Komander, D. (2012). An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat. Struct. Mol. Biol. 19: 62–71.